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Headache : Some patients may report mild headaches, which typically resolve on their own or with the use of over-the-counter analgesics

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Genetic polymorphisms in genes encoding matrix metalloproteinases, collagen synthesis enzymes, or inflammatory mediators could theoretically influence GHK-Cu responsiveness, though systematic investigations of pharmacogenetic determinants remain absent from current literature

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doi:10.1186/1742-4933-2-17