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Nagashima M, Watanabe T, Terasaki M, Tomoyasu M, Nohtomi K, Kim-Kaneyama J, Miyazaki A, Hirano T

Median Weight Loss for Bariatric Surgery Patients Was 100 Pounds, as Opposed to 20 Pounds for GLP-1s Our survey found that for bariatric surgery patients the median weight lost was 100 pounds

Severe kidney disease (eGFR under 30) is a contraindication for metformin because of lactic acidosis risk

Hydration Drink plenty of water to support detoxification

Without that context, typical drug effects can look like red flags, leading to unnecessary worry, repeat testing, or even pressure to stop a treatment thats working

They address both the water content and motility components of GLP-1 constipation