In models of PD, curcumin activates the PI3K/Akt signaling pathway, which is crucial for promoting neuronal survival, enhancing neurotrophic support and reducing inflammation and oxidative damage, thereby improving dopaminergic neuron integrity and motor behavior (Song et al., 2021
Conversely, the body's adjustment to improved glucose regulation after periods of hyperglycaemia may temporarily affect energy levels
Links to the technology appraisal and NHS England guidance can be found in the references below
Note, endothelin per se, inhibited platelet aggregation and caused subarachnoid hemorrhage [27,28]
Rosenstock et al., 2021 SURPASS-1 (Placebo-Controlled) Rosenstock and colleagues reported SURPASS-1 in The Lancet in 2021 [4]
Semaglutide is not known to directly trigger primary neurological headaches