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Encouraged by their success with the dual agonist, Tschp and DiMarchi wondered if it was possible to go a step further and develop a peptide to simultaneously target three key metabolically-related hormone receptors: GLP-1, GIP and glucagon

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Initially, we anticipated that GEP44 would reduce serum glucose levels via binding to GLP-1R

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The direct action of GIP on its receptor, which is expressed by these cells, is what causes GIP stimulation to increase glucagon secretion by alpha cells in contrast to GLP- 1 [72,73,74]

Novo Nordisk, the parent company of Ozempic and Wegovy, reported the incidence of acute pancreatitis in their clinical trials