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The strongest mitochondrial FAO activity has been observed in the proximal and distal convoluted tubules (Wirthensohn and Guder, 1986)

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These biochemical disruptions were accompanied by a marked depletion of endogenous antioxidants (GSH, GPx, SOD, and CAT) and an elevation of the lipid peroxidation marker MDA, demonstrating a profound redox imbalance