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doi: 10.1186/s12865-017-0212-1 84 TharakanAKumarAAllegoodJCowartLAConradDHMartinRK

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Biochem Mol Biol Int 43:197205 Nielsen SF, Thastrup O, Pedersen R, Olsen CE, Christensen SB (1995) Structure-activity relationships of analogues of thapsigargin modified at O-11 and O-12

Absolute contraindications: Known allergy to either peptide or its components Active cancer (insufficient safety data) Pregnancy or breastfeeding (insufficient safety data) Severe immunocompromise (theoretical concern) Relative contraindications (require careful consideration): History of cancer (consult a medical advisor) Major cardiac disease (monitor closely) Severe liver or kidney disease (may affect clearance) Active infections (wait until resolved) Bleeding disorders (monitor injection sites carefully) Special populations: Elderly subjects: usually well tolerated, no dose adjustment needed Subjects with multiple conditions: enhanced monitoring recommended Those on multiple medications: review for possible interactions Drug Interactions The peptides have minimal documented drug interactions

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