Furthermore, the secretome of hMSC-Ex-4 displayed an altered protein profile, including enhanced secretion of insulin-like growth factorbinding protein 2 (IGFBP2) and apolipoprotein M (APOM), both of which are implicated in metabolic regulation and may contribute to the therapeutic modulation of type 2 diabetes mellitus [18]
Anti-Obesity Drug Discovery: Advances and Challenges
By targeting GLP-1, GIP, and glucagon receptors, researchers are exploring whether multi-pathway therapy can produce deeper metabolic effects than earlier medications
Unlike GnRH agonists that create an artificial menopause to suppress estrogen, the weight-mediated estrogen reduction through GLP-1 agonists is more physiological
Recent clinical trials in people in the early stages of dementia have raised the possibility that drugs that enhance GLP-1 signalling could have neuroprotective effects
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