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Calcium regulates APTF-2 binding to the glp-1 promoter Mechanistically, changes in the level of cellular Ca 2+ have been shown to affect the subcellular localization of transcription factors as well as their affinity for gene regulatory regions 37,38,39

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Aging Pathobiol Ther , 2020, 2(1): 58-61

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This can lead to poor disease control and potentially serious metabolic complications if the issue goes unrecognized for an extended period

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