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This IR cascade initiates a characteristic sequence of metabolic and oxidative perturbations within mitochondria: succinate accumulation during ischemia, reverse electron transport-driven ROS generation upon reperfusion, calcium overload, opening of the mPTP, and ultimately, release of mtDAMPs
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This means men tend to age more slowly in their 20s and 30s but when collagen loss begins in earnest in the 40s, it can progress rapidly, and the cumulative effects of years of UV exposure become dramatically visible
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