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In the STEP 3 randomised trial, once weekly semaglutide 2.4 mg used in obese adults without diabetes was associated with 4.9% incidence of gallbladder related disorders (mainly cholelithiasis) compared with 1.5% in the placebo group (1)
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Given the shortages, Lagerros, an obesity medicine specialist and associate professor at the Karolinska Institutet in Stockholm, Sweden, expected the guidance but said it was reinforced with the letters mailed to physicians' homes
May Support Appetite Regulation Semaglutide works with GLP-1 receptors that may help regulate appetite signaling - supporting reduced cravings and a greater sense of fullness between meals
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