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During weight loss, higher amounts (1.2-1.6 g/kg) may help preserve lean mass, though this should be individualized based on age, kidney function, and other health factors

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In the 12 mg arm, participants achieved a mean body weight reduction of approximately 24% at 48 weeks the highest observed across the dose groups though this arm was also associated with a higher incidence of gastrointestinal side effects

Importantly, proteolytic cleavage of SPARC (secreted protein acidic and rich in cysteine), a matricellular protein abundantly expressed at sites of vascular injury and tissue remodeling, generates GHK-containing fragments that promote endothelial cell proliferation and neovascularization