While systemic injection also delivers peptides to the brain via blood circulation, nasal delivery may provide more direct CNS access for some portion of the dose
Bonomi M, Vezzoli V, Krausz C, Guizzardi F, Vezzani S, Simoni M, Bassi I, Duminuco P, Di Iorgi N, Giavoli C, Pizzocaro A, Russo G, Moro M, Fatti L, Ferlin A, Mazzanti L, Zatelli MC, Cannavo S, Isidori AM, Pincelli AI, Prodam F, Mancini A, Limone P, Tanda ML, Gaudino R, Salerno M, Francesca P, Maghnie M, Maggi M, Persani L, on Central Hypogonadism (NICe group) (2018) Italian Network on Central Hypogonadism, Italian Network Characteristics of a nationwide cohort of patients presenting with isolated hypogonadotropic hypogonadism (IHH)
It also serves as a standard for quantifying intracellular GSH:GSSG ratios in oxidative-stress assays
Chalmers RA et al
The fatty acid acylation of cagrilintide enables albumin binding in circulation, reducing renal clearance and extending the elimination half-life to support once-weekly dosing
Body Cleanser