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Chronic alcoholic patients between the ages of 21 and 65 years were investigated for predisposition to acetaminophen hepatotoxicity caused by increased activity of the cytochrome P450 system and decreased hepatic GSH concentrations
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Notably, no sign of hepatotoxicity was reported when 4 g/d APAP was administered for up to 12 months to adult patients with osteoarthritis pain ( Reference Temple, Benson and Zinsenheim 91 )
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