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For example, Parkinsons and Alzheimers diseases have high levels of oxidative stress and damage to the brain with correspondingly low active glutathione (GSH) levels

Many patients transition to a maintenance cycle after the initial protocol period, with MOTS-c dosing spaced further apart to sustain the metabolic improvements achieved

Metabolic adaptation A compensatory reduction in energy expenditure that exceeds that predicted from changes in body mass and body composition during and after weight loss

2.2.5 Metabolic reprogramming Metabolic reprogramming refers to the process in which cells, under specific physiological and pathological conditions, systematically adjust and transform their metabolic patterns to adapt to changes in the external environment and to meet their own needs for growth and differentiation, by engaging various bioenergetic routes, such as glucose utilization, lipid metabolism, and amino acid metabolism (Xia et al., 2021