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whether and when drug applications for any potential indications for Pfizers oral GIPR antagonist candidate, other earlier obesity programs or any other product candidates may be filed in any jurisdictions

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To our knowledge, the present study is one of the first comprehensive dose-response meta-analyses to evaluate the L-carnitine effects on glycemic markers in diabetes and non-diabetic adults and we considered all published RCTs that were conducted on the effect of L-carnitine sapplementation on glycemic indices

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Vagal afferent neurons (VANs) expressing GLP-1Rs innervate intestinal mucosa and hepatic portal vasculature, suggesting these pathways may transduce peripheral GLP-1 RA effects to central satiety and glucoregulatory centers 57,58,59