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In the SUSTAIN-6 trial, semaglutide was associated with a significant increased risk of diabetic retinopathy complications, including vitreous hemorrhage, blindness, or conditions requiring treatment with an intravitreal agent or photocoagulation (HR 1.76, 95% CI 1.112.78) [27]
The soluble fraction was clarified by centrifugation (4 C, 14000 x g, 30 min) and was filtered through 0.22 m filter
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Considerable between-individual and within-individual variability was observed for oral semaglutide bioavailability, which is usual for molecules with low bioavailability [22]
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