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348 Similarly, in human chondrocytes stimulated by TNF, GLP-1 analogs (such as liraglutide) showed an anti-catabolic effect, reducing the mRNA expression of MMP-3, MMP-13, and ADAMTS5

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These cytokines orchestrate the recruitment, activation, and fibrotic processes of inflammatory cells, engaging signaling pathways like NF-B and Smad, along with oxidative stress mechanisms and cellular interactions [184, 185]

While some people use this antioxidant specifically for skin support, an excess can occasionally lead to hives or mild dermatitis