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While Michaels noted that FDA-approved GLP-1s can be appropriate under medical supervision for individuals with severe obesity or chronic health conditions, she warned that using them or unapproved peptides for minor weight loss carries risks that users overlook

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Importantly, no large-scale randomised controlled trials have established MT-II as a safe or effective treatment for ED

For individuals with a body mass index (BMI) of 30 kg/m or above (or 27.5 kg/m for people from South Asian, Chinese, other Asian, Middle Eastern, Black African, or African-Caribbean backgrounds), NICE recommends considering pharmacological interventions alongside lifestyle changes when dietary and exercise modifications alone have been insufficient

The 57% maintenance-dose figure Only 57% of the CagriSema group in REDEFINE 1 actually reached the planned 2.4/2.4 mg maintenance dose by the end of the build-up period