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Northern analysis related the decreased amounts of TAFC in egtA yap1 consequent to a down-regulated expression of sidG (AFUA_3G03650), the acetyltransferase catalyzing the triacetylation of FsC to generate TAFC 34

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Both doses led to an increase in maximal respiration and ATP-linked respiration in HC cells, while mitochondrial biogenesis and oxidative phosphorylation gene expression remained unchanged, suggesting that UA specifically enhances mitochondrial respiration to improve chondrocyte metabolic function