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They include: Nausea Vomiting Diarrhea Decreased appetite Constipation Abdominal pain These gastrointestinal issues are the most frequently reported side effects, occurring in up to 20% of patients in clinical trials

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Complete, uncropped western blot images from figures are provided in Supplementary Fig

Furthermore, the gut-brain-pancreas axis is connected via the parasympathetic vagus nerve with afferent neurons linking the intestinal mucosa, portal vein and hypothalamus

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