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Computational analysis Quantification analysis of RNA-seq data was performed by Novogene Corporation Inc

Supports the immune system: Glutamine is an energy source for the immune system and supports the gut, regulates immune responses, aids recovery from an illness, and protects against immune suppression

SAM is synthesized from the essential amino acid, methionine

As S -adenosylhomocysteinase catalyses the hydrolysis of SAH, any disruption to its activity would be expected to increase SAH levels, and reduce the SAM/SAH ratio

Histidine catabolism is a major determinant of methotrexate sensitivity