Highest active glutathione form
Administered by trained professionals in a clinical setting
In the scientific literature, many hepatoprotective biologically active compounds exist, including natural and synthetic compounds 8, 9, 10, 11, 12
But it creates a temporary flood of free fatty acids entering circulation and being oxidised in the liver and muscle tissue
Conversely, knocking out the gene ECE1 that only encodes candidalysin results in a sharp decline in IECs damage, barrier disruption and penetration ability 112
An RCT of 174 patients with severe alcoholic hepatitis found that the combination of prednisolone + NAC (IV for 5 days, then oral for 2 weeks) significantly reduced 1-month mortality compared to prednisolone alone (8% vs 24%, p=0.006), though the difference was not significant at 6 months (Nguyen-Khac et al., N Engl J Med, 2011) [36]