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Weight loss improves knee OA, with studies showing a 2% improvement in the WOMAC pain, function, and stiffness scores for every 1% reduction in body weight
High body mass index (BMI) has been shown to increase joint inflammation, exacerbating pain
John Batsis, a geriatrician and obesity specialist at the University of North Carolina School of Medicine, told The New York Times in a recent report that people over 65 years old are "prime targets" for this medication, as obesity prevalence is about 40% in older adults
That precision is what makes true microdosing possible
A 2023 study found that vitamin B12 deficiency is associated with higher body weight and fat mass, according to Healthline
One study in diet-induced obese mice found that an NNMT inhibitor combined with a calorie-restricted diet was associated with shifts in gut bacterial populations, suggesting metabolic intervention can have knock-on effects on gut composition
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