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The 2022 safety analysis found monotherapy well tolerated in men with prior testosterone use, but that was under clinical supervision (Cureus, 2022)
The most commonly reported events were decreased appetite (19%), headache (12%), fatigue (11%), and COVID-19 infection (11%), most of which were mild
However, insulin remains necessary for patients with Type 1 diabetes and some advanced Type 2 patients with minimal beta cell function
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The cardiovascular safety profile appears favorable, with no increased risk of major adverse cardiac events in available data
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