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demonstrated that IAV infection induces mtROS generation, thereby causing innate immune inflammation and exacerbating viral pathogenesis in a mouse model 137
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Mechanistic experiments using the PI3K inhibitor wortmannin demonstrated that PI3K/AKT signaling is required for the anti-inflammatory and anti-apoptotic effects, identifying the brain AngIV/PI3K/AKT axis as the proximate mechanism in this model
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