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16 LosurdoG.GiorgioF.IannoneA.PrincipiM.BaroneM.Di LeoA.et al (2016)

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Excess B12 from oral supplements is poorly absorbed at high doses (the body absorbs roughly 1 to 2% of a 1,000 mcg oral dose) and the remainder is excreted in urine

The Aib residue and C-terminal amide give good resistance to enzymatic breakdown, but the bulky aromatic D-2-naphthylalanine makes light exposure the practical risk