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For this reason, people taking orlistat are often advised to take a daily multivitamin.[1] According to the Cleveland Clinic, orlistat should be used alongside a reduced-calorie diet that contains no more than about 30% of calories from fat

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Smaller portions may help reduce digestive discomfort while supporting more consistent food intake

By this point, your body has adapted to the medication's effects, your food choices have shifted naturally to lighter, less-sweet, less-fatty options, and your appetite regulation has genuinely changed

This dual agonist medication produces about 20-22% weight loss