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ACS Infectious Diseases , 6(7), 1558-1562

Several events seen in the brain of neurodegenerative diseases could give rise to an abnormal production of reactive oxygen spices (ROS)

Relevantly, SAH is a potent inhibitor of methylation ( S -adenosylhomocysteinase activity (Liao et al., 2012)

While the simulations are confined by these assumptions, it is worth noting that redox cycling is governed by thermodynamics, which according to the reduction potential of doxorubicin, are favourable with respect to the formation of superoxide should a semiquinone radical species be present 3

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Tan KC, Ipcho SVS, Trengove RD, Oliver RP, Solomon PS (2009) Assessing the impact of transcriptomics, proteomics and metabolomics on fungal phytopathology