We first validated that TYR could catalyze the in situ generation of VHL-recruiting PROTACs to efficiently degrade TYR both in vitro and in vivo for curtailing melanin synthesis to effectively treat skin hyperpigmentation
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Dos Santos SM, Romeiro CF, Rodrigues CA, Cerqueira AR, Monteiro MC
In 2017, we reported that in certain Asian countries, women were getting glutathione injections (and probably still are) to alter their skin to a lighter, more desirable tone (though it's advised against because of limited safety data)
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Despite this, while exogenous Agm has been reported to enhance hippocampus-dependent spatial and recognition learning (McKay et al., 2002