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In addition, during diabetic wound healing, hyperglycemia, vascular occlusion, and a dysfunctional microenvironment severely impair collagen deposition and tissue remodeling

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They are not substitutes for levothyroxine or antithyroid medications but may provide incremental benefits by addressing oxidative stress, inflammation, or neurotransmitter imbalances that pharmacotherapy alone does not resolve (261, 262)

This underscores the need for new, more effective therapies