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Serotonin Syndrome Counteraction A 2005 study in the European Journal of Pharmacology (PMID: 15840402) induced severe serotonin syndrome using pargyline (MAO inhibitor) plus L-tryptophan (serotonin precursor), producing forepaw treading, hindlimb abduction, wet dog shake, and hyperthermia mediated primarily through 5-HT2A receptors
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OuJSmithRCTobeRHLinJArriazaJFaheyJWet al
These results also suggest that charge dependent adsorptive mediated transcytosis, which is prominent for cationic molecules and carriers, may not play a strong role in the internalization of drug-coupled 3-PLGs
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