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BPC-157 modulates nitric oxide signaling and upregulates VEGFR2-mediated angiogenesis
126 In an open-label controlled trial in healthy middle-aged adults, 900 mg of cocoa flavanols per day for 30 days improved endothelial function, an important factor in thrombotic risk, and in a follow-up controlled trial the same dose was also shown to improve blood pressure and lipid levels
Doses above 3 IU per day in healthy adults produce measurable IGF-1 elevation but also dose-dependent insulin resistance, fluid retention, and carpal tunnel risk documented in controlled trials
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