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This is the first pharmacological agent to show prognostic benefit in this population, offering therapeutic potential beyond symptomatic control
According to the SmPC, if a patient does not tolerate a dose increase, delaying the increase by an additional 4 weeks can be considered
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In addition, the article reviews the clinical progress of GLP-1R agonists, including their efficacy, safety and potential in the treatment of diabetes and related complications
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We also uncover how the rate of receptor agonist dissociation within the endosomal compartment predicts the rate of receptor recycling, itself a key determinant of sustained insulin secretion
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