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It helps to separate two different meanings of the word work. A peptide can be biologically active (it binds its receptor and produces an effect) yet have terrible oral bioavailability (almost none of it reaches the receptor when swallowed)

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BPC-157 for connective tissue and gut, GHK-Cu for collagen, skin and hair, MOTS-C for energy and metabolic function

Researchers are exploring its ability to promote tissue regeneration in the GI tract and reduce intestinal permeability

The following comparison summarizes the key considerations: For patients with intact GI absorption, oral high-dose supplementation (1,000 to 2,000 mcg daily) provides a convenient and cost-effective path to correcting deficiency