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It serves a variety of important roles in the body, including protecting cells from oxidative damage, detoxifying harmful substances like heavy metals, helping to regulate enzyme function, aiding in the formation of proteins, and maintaining the immune system
The inability of antioxidant systems, such as GPX4-dependent pathways, to counteract ROS amplifies ferroptotic damage ( 4.2 Iron overload and dysregulated metabolism Iron overload is a critical factor that drives ferroptosis and worsens ARDS pathology