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Ipamorelin is studied as a selective ghrelin mimetic it binds the growth-hormone-secretagogue receptor (GHSR-1a), the same receptor the hunger hormone ghrelin uses, and in research settings appears to stimulate GH release with relatively limited effect on other hormones such as cortisol, prolactin, and ACTH

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In August 2025, Wegovy was FDA-approved for the treatment of MASH in adults with moderate to advanced liver fibrosis (consistent with stages F2 to F3 fibrosis) based on results of the ESSENCE trial KNEE OSTEOARTHRITIS (OA) Knee osteoarthritis (OA) is caused and worsened by obesity, as both mechanical stress and obesity-induced inflammation accelerate joint destruction

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