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Symptom Monitoring: Even though serious adverse events did not occur in trials, individual monitoring for headache, gastrointestinal symptoms, or unusual effects allows for early detection of tolerability issues and appropriate management adjustments
Excess cobalamin in the blood showed barely detectable binding to TC II (Andrs et al., 2013)
The protocol was approved by independent ethics committees or institutional review boards at each study site (a redacted protocol is provided separately)
The injections should always be administered by a licensed professional, like a registered nurse or a skilled aesthetician, in a sterile setting
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