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Novo Nordisk has submitted a label extension application to the EMA and FDA

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Direct GLP-1 Receptor-Mediated Immune Modulation Semaglutide activates GLP-1 receptors on immune cells, which: Suppresses the NF-kB signaling pathway, a master regulator of inflammatory gene expression (8) Reduces the production of pro-inflammatory cytokines (IL-6, TNF-alpha, IL-1beta) Shifts macrophage polarization from the pro-inflammatory M1 phenotype toward the anti-inflammatory M2 phenotype (10) Modulates T-cell responses, potentially reducing autoimmune-driven inflammation Weight Loss and Visceral Fat Reduction Visceral fat is not merely a storage depot it is an active endocrine organ that produces a constant stream of inflammatory cytokines

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Another study found that the drugs that stimulate oxytocin release, including melanotan 1 and melanotan 2, promote social bonding (induced partner preference) in female prairie voles, a specie with complex social behavior [12]

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