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Separate solutions of fragments in dimethylsulfoxide (DMSO)/acetonitrile (ACN), [Ethyl-cyano (hydroxyimino) acetato-O2] tri-1-pyrrolidinylphosphonium hexafluorophosphate (PyOxim) in ACN, and N,N0-diisopropylethylamine (DIPEA) were prepared and combined in continuous flow within the PFR

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