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Generation of 2A -adrenergic receptor knockout cell line We employed a CRISPR-Cas9-mediated approach to delete endogenous 2A -adrenergic receptor expression in INS-1E cells

Approximately 10% of energy-controlling gene expression, including those encoding nuclear hormone receptors and glucose and lipid metabolism enzymes, are regulated by circadian rhythm in a tissue-specific manner (Panda et al., 2002

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