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Markell D, Peterson D

Additionally, mTOR promotes the translation of HIF-1 mRNA

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Further, animal studies indicate that it may strengthen the gut-brain axis, improving feedback between the GI tract and the central nervous system to elicit systemic effects [2, 4, 11]

Additionally, GIP receptor expression in hypothalamic regions and oligodendrocytes suggests central nervous system actions that may synergize with GLP-1 to reduce appetite and food intake while potentially mitigating GLP-1-associated nausea, thereby improving treatment tolerability [36,41,42]

Proponents say horse-derived collagen has a higher protein bioavailability and a specific amino acid profile (glycine, proline, hydroxyproline) that triggers satiety hormones and supports connective tissue repair