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They do not demonstrate tissue-specific targeting in people
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Weight loss outcomes differ based on individual factors such as starting weight, adherence, and lifestyle habits
These secretagogues are distinct from the growth hormone-releasing (GHR) or Growth Hormone Releasing Peptide (GHRP) in that they share no sequence relation and derive their function through action at a completely different receptor, the ghrelin receptor
Drugging this type of GPCR with small molecules has its challenges say Jeff Finer, chief executive of Septerna, a biotech based in south San Francisco, US
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