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In the fasted state, allulose passes through the gastrointestinal tract too rapidly to elicit any meaningful hormonal responses

Insulin sensitivity also follows a circadian rhythm

The breakdown of oral glutathione in the gut is driven partly by the enzyme gamma-glutamyltransferase, which is why a conventional tablet raises blood glutathione only slightly (Buonocore et al., Oxidative Medicine and Cellular Longevity 2016, PMID 26649136)

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This slows cravings and aids in resisting overeating

As this in part depends on cell density and collagen accumulation, many studies have associated lower cortical ADC values and lower corticomedullary ADC differences with a higher degree of fibrosis [17, 39,40,41]