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In breast cancer patients undergoing radiotherapy, Sidr honey (1 g/kg/day) increased BRCA1 and RAD51 expression correlated with 55% less double-strand breaks (DSBs) in the tissues (p 3.0.CO;2-9 59 TomasinRGomes-MarcondesMC

Sources of Funding This work was supported by PRIN (funding for research of national interest provided each year by MIUR, the Italian Ministry of Education) no

(PubMed) Weekley CM, Harris HH

certificate of analysis available on request Research Applications Suitable Laboratory Uses for FOXO4-DRI FOXO4-p53 protein-protein interaction disruption assays CO-IP, competitive binding, and proximity ligation studies Selective senescent cell apoptosis induction SA--gal, p16, p21, p53 marker-confirmed senescent populations p53 TAD2 binding, phospho-p53 (Ser15) nuclear exclusion, and mitochondrial translocation pathway studies BAX/BCL-2/Caspase-3 intrinsic apoptosis cascade investigations in senescent cell models SASP characterisation and suppression IL-6, IL-8, MMP, VEGF, CXCL2/3 secretome studies Tissue-specific senescence models fibroblasts, endothelial cells, Leydig cells, chondrocytes, keloid fibroblasts Vascular ageing pathway research endothelial senescence, aortic function, and ROS pathway studies Senescent cancer cell biology and drug resistance pathway research Comparative senolytic research FOXO4-DRI vs

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