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The Pharmacology of Liraglutide and Semaglutide Liraglutide and semaglutide are both long-acting GLP-1RAs that, despite differing administration intervals and doses, have pharmacodynamic (PD) effects for 24 h/day (124, 125)

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The Core Rule: The 72-Hour Minimum The most important guideline provided by the manufacturer and healthcare professionals is the 72-hour rule