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Other (less serious) concerns are if EGF can properly penetrate the skin (as it is a medium-sized, polar molecule, so a special delivery system is probably needed), if it can affect collagen synthesis (or just works on the surface plumping up only the upmost layers of the skin) and if it has beneficial effects at all when used in isolation versus when used in a "conditioned media" that contains lots of growth factors resembling the synergistic balance found in the skin
Hurtado, Maria D., et al
Unlike many other therapeutic compounds, BPC-157 works through multiple pathways in the body
SmirmaulBPCChamonRFde MoraesFMRozinGMoreiraASBde AlmeidaRet al
For neurological applications, the evidence is more preliminary and the extrapolation from rodent to human more uncertain
According to Alberta Blue Cross, emerging therapies in this class are expected to be more effective, have broader uses, last longer between doses and will increasingly be available in oral form
