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Patent CN105154498a example 10 discloses Arg34GLP-1 (9-37) main peptide chain is coupled with side chain with carboxyl protected by tert-butyl (tBu), then coupled with Boc-His (Boc) -Aib-OH dipeptide in presence of HATU and TEA, reaction time is as long as 14 days, freeze-drying time is as long as 16 hours after HPLC purification by post-treatment, which is not good for industrial production, and Boc has no strong absorption of Trt in ultraviolet, which is not good for reaction monitoring, and Boc has no good stability of Trt, which results in generation of racemic impurities
For those unfamiliar, GLP-1 agonists are primarily recognized for their role in weight loss and diabetes management
Compounded tirzepatide has shorter room-temperature stability, typically 3-7 days depending on formulation
Treats serious skin problems like hyperpigmentation and melasma, sunspots, etc
Thus, the hemolytic profile of SR18 was evaluated using a standard hemolytic assay by incubating freshly isolated human erythrocytes with SR18 at concentrations ranging from 0.39 to 100 M
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