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FAK and Pyk2 activity promote TNF- and IL-1-mediated pro-inflammatory gene expression and vascular inflammation
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Additionally, certain conventionally dominant commensal bacteria like Faecalibacterium prausnitzii , which plays a critical role in maintaining immune homeostasis by inhibiting the NFB signaling pathway and cytokine production and increasing colonic epithelial tight junction proteins, is significantly reduced in both IBD and PD (Laval et al., 2015
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Siebenhaar F, Frtsch A, Krause K, Weller K, Metz M, Magerl M, et al