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Some researchers report stable results up to 45 or 60 days, but 28 days is the window within which potency is most reliably maintained
Gut Pathog
Bioprocess Biosyst Eng 33:675682
Lack of sleep also makes you hungrier, causes you to store more fat, and makes your body less sensitive to the hormone insulin, sabotaging attempts to lose weight and increasing your risk of developing type 2 diabetes or cardiovascular disease
However, some people may experience side effects
PMID: 81 ZhangJJinPPGongMGuoJHFangKYiQTet al
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