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Senescent cells accumulate over time and are characterized by altered gene expression, resistance to apoptosis, and secretion of inflammatory mediators collectively referred to as the senescence-associated secretory phenotype (SASP)

M Diotallevi, P Checconi, AT Palamara, et al

Remarkably, the TSS pathway is compensatively activated when the extracellular source of cystine is restricted or under extreme oxidative stress conditions

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Leptin transmits energy store information to the hypothalamus and influences gonadotropin secretion

Rietjens IM et al